King Tontown Medical Instruments Group Co.,Ltd

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Analysis on Clinic Application with 243 Cases The first Military Medical University, Zhujiang Hospital
Cardio-/cerebrovascular diseases are common and frequently-incurring diseases which seriously threatens the health of human being. With the increasing improvement of people's material living standards, the attack rate of this disease increased year on year. As the demands for health and living quality increase, it becomes more difficult to prevent this illness. For decades, people have been committed to the research on the prevention and cure of cardio-cerebrovascular disease, especially in recent years, more and more treatment methods and medicines have emerged, the effect is not so satisfying. Our hospital had been using the “Cardio-/Cerebrovascular Therapeutic Instrument” of King Tontown Medical Instrument Co., Ltd. from April 1995 to September 1996, giving a better clinic effect on 243 cases with Cardio-/Cerebrovascular Disease. Now, we report the results as below:

I. General Information
243 patients include 110 male patients and 133 female patients, aged from 23 to 82 years old averaging at 57.25±15.33 years old. These patients can be divided into the following groups:
1. Coronary heart disease: 44 cases, the duration of illness varied from 2 months to 6 years. The main symptoms included chest distress, palpitation and angina pectoris. ECG showed myocardial ischemia, and some with different types of abnormality of heart rhythm, such as atrial or ventricular premature beat, auriculo-ventricular block (AVB) and atrial fibrillation.
2. High Blood Pressure: 40 cases with more than 1 year of course of illness. The systolic pressure was 22-26Kpa averaged at 2.72±2.88Kpa, and the diastolic pressure was 13-17.3Kpa, averaged at14.04±1.84Kpa.

3. Cerebral Infarction: 52 cases with the duration of illness from1 week to 3 years, all transferred from the Department of Neurology with CT-conformed diagnose.
4. Cervical Dizziness: 32 cases, the illness lasted 4 days or 3 years with the main symptoms like dizziness, nausea, vomiting, and the activities of head and neck were limited.The Cerebral Blood Flow showed that vertebral basilar artery had no sufficient blood supply, and X-ray film showed that it matched the change of cervical spondylosis.
5. Autonomic Nerve Disorder: 38 cases including 30 cases with functional sleep disorder, 3 cases with stomach intestine autonomic nerve disorder and 5 cases with heart autonomic nerve disorder.
6. Post-Cerebral Trauma Syndrome: 8 cases showing headache, dizziness, head nesthesia and feeling of distress.
7. Others: 29 cases including 6 cases with chronic renal insufficiency, 10 cases with lumbocrural pain, 5 cases with rheumatoid arthritis, 4 cases with diabetes, 2 cases with Parkinson’s disease, 1case with paraplegia after meningioma operation and 1 case with Guillain-Barre Syndrome.
II. Methods
1. Therapeutic Methods:
By using the Cardio-Cerebrovascular Therapeutic Instrument (hereafter called as “CCTI”) produced by King Tontown Medical Instrument Co., Ltd, this instrument will output the alternating electromagnetic wave. When starting this instrument, the patient need to lay on a specific therapeutic bed for 30-40 minutes per time, one time per day. One course of treatment needs 10 times, and generally the patient should continue the treatment for 2-3 courses. II. Lipoprotein & Subcomponent Test: Using enzyme-linked method to test the lipoprotein and its subcomponent before and after the treatment.
3. Blood Rheology: draw 5ml venous blood respectively before treatment and after 20 time of treatment with the NXE-1 conical viscometer of Chengdu Instrument Factory to test the whole blood viscosity (under high and low shear rate) and the plasma specific viscosity.
4. To have ECG, Cerebral Blood Flow and blood pressure tests on patients with coronary heart disease, cerebral infarction, high blood pressure and cervical dizziness before and after treatment.
5. Assessment Standards for Therapeutic Effect: based on Treatment Standards for Clinic Diseases Diagnose stipulated by the Department of Health of General Logistics Department, PLA.
6. Data Processing: all data were put in the computer and processed by Microsoft Excel5.0 statistics software to calculate the average, standard deviation and to have T-test for the matched data.

III. Results
1. Analysis on Therapeutic Effects
This paper involved 243 cases including 117 cases with apparent effect, taking up 48.15%, 90 cases turning better, 37.04%. The effectiveness was 85.19 and ineffectiveness took up 14.81%. Among these patients, those with cardio-/cerebrovascular disease are the majority, and they all were with better therapeutic effect. Compared with other diseases, P is less than 0.05, meaning that there was obvious difference. Patients with autonomic nerve disorder had a better result with the effectiveness of 97.3%. However, this instrument has little effect to some non-cardio-/cerebrovascular diseases with an effectiveness of 48.28%.（See Table 1）

Table 1 Therapeutic Effect
Disease Case	Apparent Effect	Turn Better	Ineffective	Noneffective
Coronary heart disease	44	20	18	6
High Blood Pressure	40	24	14	2
Cerebral Infarction	52	26	22	4
Cervical Dizziness	32	16	12	4
autonomic nerve disorder	38	25	12	1
Post-Cerebral Trauma Syndrome	8	2	2	4
Others	29	4	10	15
Total	243	117（48.15%）	90（37.04%）	36（14.81）

2. Average for all Therapeutic Effects
Shown as Table 2, 24 patients received 16.1 times of treatment averaged. The average for Apparent Effect, Turn Better and Ineffective was 21.5, 12.3 and 8.2 times respectively. So we could conclude that the effectiveness is directly proportional to the therapeutic times. In Table 1, the patients who failed to cure the cardio-/cerebrovascular disease did not insist the treatment for one course. For the patients with autonomic nerve disorder, especially for the neurasthenic, this instrument began to works after 5 times, and after one course of treatment, the therapeutic target will be achieved.

Table 2 Average Times
	Apparent Effect	Turn Better	Ineffective	Total
Case	117	90	36	243
Average	21.5	12.3	8.2	16.1

3. Analysis on Blood Pressure before and after Treatment
We tested 40 HBP cases’ blood pressure before and after the treatment, and found that after treatment the patients’ systolic and diastolic pressure reduced obviously. After statistics processing, P <0.001, showing a great difference (See Table 3).

Table 3 Blood Pressure Change before and after Treatment (n=40)
Blood Pressure	Pre-treatment	Post-treatment	P
systolic Pressure (Kpa)	22.72±2.88	17.41±1.49	<0.001
Diastolic Pressure(Kpa)	14.04±1.84	11.17±1.17	<0.001

1. Analysis on Serum Lipoprotein and Subcomponent before and after treatment (See Table 4)

Table 4 Changes of Lipoprotein and Subcomponent before and after treatment(X±S)
Lipoprotein and Subcomponent	Pre-treatment(n=55)	Post-treatment(n=55)	P
TG（mmol/L）	2.37±1.24	1.69±0.91	<0.01
TC（mmol/L）	5.31±1.30	4.66±1.04	<0.001
LDL-c（mmol/L）	3.76±0.98	3.11±0.88	<0.001
HDL-c（mmol/L）	1.09±0.26	1.43±0.23	<0.001
HDL2-c（mmol/L）	0.35±0.16	0.49±0.13	<0.001
HDL3-c（mmol/L）	0.74±0.18	0.94±0.15	<0.001
TC/HDL-C	4.9±1.5	3.3±1.4	<0.001
LDL-C/HDL-C	3.4±1.1	2.2±1.2	<0.001
HDL2-C/HDL3-C	0.47±0.20	0.52±0.18	<0.05

2. Analysis on Blood Rheology before and after Treatment

Table 5 Changes of Blood Rheology Index (X±S）before and after Treatment
	High-shear Whole Blood Viscosity (mpa.s)	Low-shear Whole Blood Viscosity (mpa.s)	plasma specific viscosity(mpa.s)
Pre-treatment(n=22)	7.58±0.75	8.67±0.82	1.83±0.12
Post-treatment(n=22)	6.63±0.58	7.76±0.77	1.68±0.10
P	<0.001	<0.001	<0.001

Note: the shear rate for high-shear viscosity is 230S-1, and the rate for low-shear viscosity is 5.57S-1.

IV. Discussion
Atherosclerosis is the most common type of arteriosclerosis, which can damage the great and mid-sized arteries including the coronary arteries and cerebral arteries leading to the damage of Cardio-/Cerebrovascular functions which can cause severe symptom, even death. During the development of atherosclerosis, there are many dangerous factors, among which the abnormity of lipoprotein constitutes the major danger. Therefore, the research on the components of lipoprotein plays an import role in the prevention of formation of atherosclerosis, slowing-down of depravation and how to eliminate the atherosclerosis. The studies show that cholesterol (chol) plays an important role in atheromatosis. It is known that the serum total cholesterol (Tc) is carried by three types of lipoprotein: LDL-c, VLDL-c）and HDL-c, among which the chol in takes up 60% of Tc. As the main carrier of serum chol, LDL-c has participated in the formation of atheromatosis. HDL-c is the antipoter protein of the inside Tc with the function to prevent the cells from intaking cho and to transport cho to the liver for decomposition and excretion. Therefore, the decrease of viscosity of Tc, LDL-c and VLDL-c and the increase of HDL-c Viscosity will help fight against the atheromatosis and reduce the attack of Cardio-/Cerebrovascular Disease. At present, it is generally believed that the rate of Tc/HDL-c or the rate of LDL-c/HDL-c can better reflect the development of the illness, so in recent years there are many research focusing on the change of the ratio. The studies prove that the physical therapy has certain effect on the metabolism of lipoprotein. As Dong Shengzhang and Zhong Saixian reported, the magnetic-treated water can reduce the cho and TG in animal’s serum and increase HDL [1.2]. Wang Jianguo and Zhao Yutang used the low-frequency pulse current and ultra-short wave to reduce the viscosity of TG and cho to [3.4]. Pan Wengan reported that the high-voltage electrostatic field with certain strength could reduce the total fat content in plasma. They think that physical agents can change the physical properties of some substances, such as surface tension, viscosity, ion solubility, permeation pressure, Ph value and enzyme activity, and improve the metabolism of lipoprotein via nerve-body fluid system, for example, cho’s synthesis will drop down, and takedown and excretion will increase. However, we never see the reports about the effect of alternating electromagnetic wave against the metabolism of lipoprotein. This paper applies “CCTI” alternating electromagnetic field to act on human body, and its results show that the “CCTI” can decrease TG, Tc, LDL-c and increase HDL-c in the serum, and make the rate of Tc/HDL-c or LDL-c/HDL-c lower down, playing a significant meaning to the prevention and curing of Cardio-/Cerebrovascular Disease.
There is a close relationship between the blood rheology and the occurrence and development of cardio-/cerebrovascular diseases. Arteriosclerosis, myocardial infarction and cerebrovascular diseases always occur with the abnormity of the blood rheology. Studies shows that before some cardio-/cerebrovascular diseases occur with apparent symptoms, there are always some alternations of blood viscosity factors, and the blood rheology takes an important role in some basic pathological course such as inflammation, arteriosclerosis and formation of thrombus. Therefore, the improving of the nature of blood rheology lays a significant meaning to the prevention and curing of cardio-/cerebrovascular diseases. According to the report of Zhang Zeshu and Li Saishan, the physical agents can change the characteristic of blood rheology [6.7]. The blood viscosity is a comprehensive index, the main mechanic characteristic of blood and the main subject of blood rheology research. This paper observed 22 cardio-/cerebrovascular diseases cases on the blood viscosity before and after treatment. The results show that there is obvious decrease in high-shear whole blood viscosity, low-shear blood viscosity and the plasma viscosity, and after statistics processing,P<0.001, with obvious difference (See Table 5). The operation system is: with the action of the alternating electromagnetic filed of “CCTI”, the films (including the enzyme, receptor, surface charge distribution) will change and electrolyte's ion will move and inside permeation pressure and PH value will also change. These changes are the main factors influencing the blood ryheology. In addition, some materials show that the blood viscosity is related negatively with the content of HDL-c but actively related with LDL-c and TG [8]. The results in this paper indicate that the content of TG, Tc and LDL-c can be reduced and HDL-c can be increased to reduce the blood viscosity and change the characteristics of the blood ryheology. This paper involves 243 cases including 117 cases with apparent effect, taking up 37.04% with an effectiveness of 85.15% which is lower than that in prior reports [9]. This may be because there are some patients who failed to maintain one course of treatment excluded in the statistics (Table 1). However, it also can prove that CCTI has a clear effect on the curing of the Cardio-/cerebrovascular diseases. This is because CCTI can effectively change the composition of serum lipoprotein and lower down the blood viscosity so that it can improve the blood supply of Cardio-/cerebrovascular blood vessels. Meanwhile, the electromagnetic wave produced by this instrument can adjust the nerve system, especially for the autonomic nerve system. It can change the elasticity of the whole blood vessels and reduce the surrounding resistance. Therefore this instrument gives a positive effect to the ischemic cardio-/cerebrovascular diseases and can also lower down the patients’ blood pressure. For example, 40 cases with high blood pressure reduced the systolic pressure and diastolic pressure 0.01 (Table 3). As CCTI can improve the composition of lipoprotein and the blood viscosity, it also has clear stimulation on the blood supply of vertebral basilar artery. As a result, it can cure the cervical dizziness. Among 32 cases herein, 16 cases’ Cerebral Blood Flow showed normal and all symptoms disappeared, 12 cases improved in the Blood Flow and symptoms. From Table 2, the effectiveness is proportional to the times and period of treatment. As long as the patients follow doctors’ advice, better results will be obtained; otherwise it will effect the final results.
In the obvious effect again the cardio-/cerebrovascular diseases, and As CCTI can adjust the nerve system, especially for the autonomic nerve system, it also has good effect on the disorder of autonomic nervous functions, especially to the nervosism patients. This paper involves 38 cases including 25 cases with Apparent Effect and 12 cases turned better with an effectiveness of 97.37%, higher than the total effectiveness. From the one year of experience, we believe that CCTI has not only obvious therapeutic effect on nervosism patients, but also with less treatment. Generally, it will show effective after more than 5 times of treatment and 10 times will provide you a satisfying result. Except the obvious effect from specific treatment on “Functional Sleep Disorder”, most patients said that CCTI could improve the sleep quality and give them a better spirit. This is also because the electromagnetic filed can adjust the autonomic nerve system. For non- cardio-/cerebrovascular diseases, this instrument has a poor performance, for example, among 36 cases, 15 cases are with other diseases. As for the side effects and therapeutic reflection, there was no side effect found on the 243 cases, and only several patients felt palpitated and chest distressed at the beginning. After explanation, they continue to use CCTI treatment, all abnormal disappeared after 5 times of treatment.
It is concluded that CCTI can effectively improve the lipoprotein and its subcomponent, lower down the blood viscosity and change the characteristics of the blood rhyeology. The results of clinic application sound satisfactory without any side effects. So CCTI has a broad prospective for the cardio-/cerebrovascular diseases. It is also more important for the prevention of such diseases.

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